I woke up at 7plus so decided to bath and head to Dear's house. :) Now I'm waiting for my surprise. I'm studying Bio now. :) About Crushing syndrome. Again, if you want to know more, continue to read ba...

It is caused by a chronic exposure to excessive circulating glucocorticoids. Glucocorticoids are a type of steriods. It is due to long term therapy on these steriods medications.

The main features that these patients have are: Moon shape face, fats being redistributed to only face and the body trunk. They will have very thin limbs and have buffalo hump on the back of their neck. The antagonistic effect of cortisol to action to insulin is hyperglycemia. It will cause diabetes in other words. However if the steriods are stopped, this condition will go back to normal. Its important to check the glucose level.

The other effects include increased protein catabolism like muscle wasting, thinning of the skin, striae(lines or stretch marks on the skin), easy bruising, osteoporosis, purplish striae on the breast and arms. For the mineralcorticoids effects which is hypertension.The enzyme aldosterone is associated with mineral glucocorticoids which act by reabsorbing water ad sodium. The BP will increase due to the increased work load of the heart to pump harder to excrete the excess water.

Inhibitory effecs on immune cells which will increase susceptibility to infections. Patients have to avoid crowded places. It will affect the brain cells causing psychiatric effects and hirsutism for androgenic effects.